diff between physiological and pathological jaundice

Explain the difference between acute and chronic bilirubin encephalopathy.ħ. Explain the difference between physiological and pathological jaundice.Ħ. Identity the normal levels of newborn bilirubin specific to different populations.ĥ.

List the normal physiological reasons for higher bilirubin levels to be present in the neonate.Ĥ. Identify the types of bilirubin, and how each type can impact the body.Ģ. Upon completion of this program, the learner will be able to:ġ. Holly Scholles examines the evidence, the fear, and the little known facts about neonatal jaundice and bilirubin in this comprehensive course. Will be jaundice all over and may appear a muddy yellow color.Bilibubin can be a dangerous neurotoxin.īut did you know that it is also a helpful antioxident? It may persist for more than 2 weeks in some conditions when the baby It is significant in the first 24 hours of life especially if

That alter the usual process involved in bilirubin metabolism in the liver.

Pathological jaundice refers to jaundice that arises from factors Other Factors which may increase Physiological Jaundice This type of jaundice is the consequence of immature liver enzymes and high red cell mass. It occurs because of physiological changes taking place during the transition from intrauterine to neonatal life. Physiological jaundice occurs in the first few days after birth and will have cleared by day 10. Original yellow deposits fade leaving dead neurons resulting in permanent brain injury. This staining is permanent, which is why high serum bilirubin levels are so dangerous. It is broken down to be excreted.īilirubin is a product of this last process and the accumulation in the blood causes yellow staining on the skin.īilirubin can cross the blood/brain barrier and stain the basal ganglia, hippocampus, cranial nerve nuclei, cerebellar nuclei, and inferior olivary nuclei. The Haem is an iron compound and so can’t be re-used. The globin is a protein that is re-used by the body. The hemoglobin is broken down into its two constituents: Haem and Globin. When a red blood cell reaches the end of its life, the reticuloendothelial system takes it out of circulation. Hemoglobin is contained in the red blood cells and its most important function is to carry oxygen to the tissues. Therefore causing Physiological jaundice.īilirubin is a product of hemoglobin breakdown. In the first week of life, the baby’s Hb will drop to about 11g/dl and this breakdown of the fetal RBCs may cause bilirubin to exceed the plasma carrying capacity of the blood. This is necessary during fetal life to facilitate oxygen-carrying capacity.Īs soon as the baby is born and able to breathe oxygen the high Hb level is not needed and starts to drop. Predisposing factors of Neonatal JaundiceĪ newborn baby has a hemoglobin (Hb) level of 18-19g/dl.

The term Jaundice comes from the French word jaundice, which means yellow thus a jaundiced baby is one whose skin color appears yellow due to bilirubin.īilirubin level of more than 85 umol/l (5 mg/dL) manifests clinical jaundice in neonates whereas in adults a level of 34 umol/l (2 mg/dL) would look icteric. Neonatal jaundice is a yellow discoloration of the skin and mucous membranes as a result of raised bilirubin levels occurring in the first 28 days of life.

Diff between physiological and pathological jaundice